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Timolol vs lumigan ol. In a randomized double-blind trial, both agents improved quality of life in patients with severe hypertriglyceridemia [17]. In that patient population, the addition of 2 gm/day metformin to lumiganol resulted in significant improvements dyslipidemia and all-cause mortality (RR 0.65 compared with RR 0.46; P less than 0.05) [17]. In a randomized double-blind study, 2 gm/day of metformin was superior to 4 gm/day of metformin for lowering LDL-, total- and triglyceride-cholesterol concentrations [18]. In a Anti fungal cream to buy large retrospective study of 7,622 patients with hypertriglyceridemia, metformin was superior to metoprolol in the treatment of hypertriglyceridemia (relative risk 0.48, absolute difference 0.21 mg/dL) [19]. In a large retrospective study of 5,433 patients with severe hypertriglyceridemia, the addition of 2 gm/day metformin to lumiganol, which was Paroxetina american generics associated with a relative risk of 0.51 (absolute difference 0.23 mg/dL), was superior to lumiganol alone in reducing dyslipidemia [20]. A clinical study of 5,739 patients with hypertriglyceridemia found that 4 gm/day of metformin (combined with statin) increased serum total-cholesterol concentrations by 9% (absolute difference 2.25 mg/dL) and the risk of developing coronary heart disease by 2% [21]. Another study of 2,567 patients with hypertriglyceridemia found that 3 gm/day of metformin was superior to 3 gm/day of metoprolol alone in the treatment of dyslipidemia [22]. A prospective study of 1,065 patients in the United Kingdom found that 1,000 mg metformin was superior to placebo in lowering all-cause mortality, and 1,400 generic xalatan price mg metformin was superior to 1,300 mg of metoprolol with regard to preventing cardiovascular events [23]. In a large randomized trial of 8,966 overweight or obese patients with cardiovascular disease, the addition of 2 gm metformin to 1,000 mg of warfarin was superior to 1,000 mg of metformin alone for lowering LDL-cholesterol concentrations and diastolic blood pressure [24]. In a retrospective study of 4,838 patients with hypertriglyceridemia, a meta-analysis of 4 randomized double-blind trials found that 2 gm of metformin was superior to 4 gm of metformin in reducing dyslipidemia (RR 0.57, P less than 0.01) and all-cause mortality (RR 0.53, P less than 0.01) [25]. In a randomized trial of 8,076 patients, metformin was superior to metoprolol in lowering LDL-cholesterol, triglyceride and apo C-III concentrations, in reducing the risk of coronary heart disease [26]. In a randomized trial of 4,567 patients, a 4-month run-in and 6-month follow-up of metformin in addition to statin therapy reduced the risk of heart failure [27]. In a prospective study of 9,000 patients with heart failure, metformin was superior to rosuvastatin and simvastatin in lowering LDL-cholesterol by 3% [28]. There were two published randomized trials of metformin in patients with high-risk hypercholesterolemia. The first study, "Lifestyle Heart Trial" conducted from 1994 to 1997, included 888 patients with the metabolic syndrome and was an open-label, randomized, double-blind clinical trial [29]. In a 2-year follow-up, these patients were found to have significantly lower LDL-cholesterol levels and were significantly less likely to have cardiovascular events than were the patients who randomly assigned to treatment and placebo. The 2nd and largest study of metformin in hypercholesterolemic patients, the "Clinical Diabetes Prevention Trial" of more than 500 patients from 1998 to 2001, was also open-label, randomized and double-blind [30]. In this study, patients were randomized to receive either metformin (0.4 or 0.8 g/day for 8 weeks) or placebo. The objective of study was to determine whether metformin could improve the cardiovascular risk profile in patients with severe, hypercholesterolemic hypertriglyceridemia. This trial lasted for 6 years and found that metformin was superior to placebo in reducing the risk of death and myocardial infarction in patients with high-risk hypercholesterolemia [30].

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